Colonisation of antibiotic resistant bacteria in a cohort of HIV infected children in Ghana.
Identifieur interne : 000092 ( Main/Exploration ); précédent : 000091; suivant : 000093Colonisation of antibiotic resistant bacteria in a cohort of HIV infected children in Ghana.
Auteurs : Eric Sampane-Donkor [Ghana] ; Ebenezer Vincent Badoe [Ghana] ; Jennifer Adoley Annan [Ghana] ; Nicholas Nii-Trebi [Ghana]Source :
- The Pan African medical journal [ 1937-8688 ] ; 2017.
Descripteurs français
- KwdFr :
- Adolescent, Antibactériens (pharmacologie), Bactéries (isolement et purification), Enfant, Enfant d'âge préscolaire, Femelle, Ghana (épidémiologie), Humains, Infections bactériennes (microbiologie), Infections bactériennes (épidémiologie), Infections à VIH (), Multirésistance bactérienne aux médicaments, Mâle, Partie nasale du pharynx (microbiologie), Prévalence, Résistance bactérienne aux médicaments, Tests de sensibilité microbienne.
- MESH :
- isolement et purification : Bactéries.
- microbiologie : Infections bactériennes, Partie nasale du pharynx.
- pharmacologie : Antibactériens.
- épidémiologie : Ghana, Infections bactériennes.
- Adolescent, Enfant, Enfant d'âge préscolaire, Femelle, Humains, Infections à VIH, Multirésistance bactérienne aux médicaments, Mâle, Prévalence, Résistance bactérienne aux médicaments, Tests de sensibilité microbienne.
English descriptors
- KwdEn :
- Adolescent, Anti-Bacterial Agents (pharmacology), Bacteria (isolation & purification), Bacterial Infections (epidemiology), Bacterial Infections (microbiology), Child, Child, Preschool, Drug Resistance, Bacterial, Drug Resistance, Multiple, Bacterial, Female, Ghana (epidemiology), HIV Infections (complications), Humans, Male, Microbial Sensitivity Tests, Nasopharynx (microbiology), Prevalence.
- MESH :
- chemical , pharmacology : Anti-Bacterial Agents.
- complications : HIV Infections.
- epidemiology : Bacterial Infections, Ghana.
- isolation & purification : Bacteria.
- microbiology : Bacterial Infections, Nasopharynx.
- Adolescent, Child, Child, Preschool, Drug Resistance, Bacterial, Drug Resistance, Multiple, Bacterial, Female, Humans, Male, Microbial Sensitivity Tests, Prevalence.
Abstract
Antibiotic use not only selects for resistance in pathogenic bacteria, but also in commensal flora of exposed individuals. Little is known epidemiologically about antibiotic resistance in relation to people with HIV infection in sub-Saharan Africa. This study investigated the carriage of antibiotic resistant bacteria among HIV infected children at a tertiary hospital in Ghana. One hundred and eighteen HIV positive children were recruited at the Korle-Bu Teaching Hospital in Ghana and nasopharyngeal specimens were collected from them. The specimens were cultured for bacteria, and the isolates were identified by standard microbiological methods. Antibiotic susceptibility tests were carried out on selected bacterial organisms by the Kirby Bauer method. Bacteria isolated from the study subjects included Moraxella catarrhalis (39.8%), coagulase negative staphylococci (33.1%), Streptococcus pneumoniae (30.5%), diptheroids (29.7%), viridian streptococci (27.1%), Staphylococcus aureus (22.0%), Citrobacter spp. (4.2%) and Neisseria meningitidis (0.9%). Prevalence of antibiotic resistance of S. pneumoniae ranged from 5.6% (ceftriaxone) to 58.3% (cotrimoxazole), M. catarrhalis ranged from 2.1% (gentamicin) to 80.6% (ampicillin), and S. aureus ranged from 7.7% (cefoxitin) to 100% (penicillin). The prevalence of multiple drug resistance was 16.7% for S. pneumoniae, 57.4% for M. catarrhalis and 84.6% for S. aureus. HIV infected children in the study area commonly carry multi-drug resistant isolates of several pathogenic bacteria such as S. aureus and S. pneumoniae. Infections arising in these patients that are caused by S. aureus and S. pneumoniae could be treated with ceftriaxone and cefoxitin respectively.
DOI: 10.11604/pamj.2017.26.60.10981
PubMed: 28451037
Affiliations:
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Le document en format XML
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préscolaire</term><term>Femelle</term><term>Humains</term><term>Infections à VIH</term><term>Multirésistance bactérienne aux médicaments</term><term>Mâle</term><term>Prévalence</term><term>Résistance bactérienne aux médicaments</term><term>Tests de sensibilité microbienne</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Antibiotic use not only selects for resistance in pathogenic bacteria, but also in commensal flora of exposed individuals. Little is known epidemiologically about antibiotic resistance in relation to people with HIV infection in sub-Saharan Africa. This study investigated the carriage of antibiotic resistant bacteria among HIV infected children at a tertiary hospital in Ghana. One hundred and eighteen HIV positive children were recruited at the Korle-Bu Teaching Hospital in Ghana and nasopharyngeal specimens were collected from them. The specimens were cultured for bacteria, and the isolates were identified by standard microbiological methods. Antibiotic susceptibility tests were carried out on selected bacterial organisms by the Kirby Bauer method. Bacteria isolated from the study subjects included Moraxella catarrhalis (39.8%), coagulase negative staphylococci (33.1%), Streptococcus pneumoniae (30.5%), diptheroids (29.7%), viridian streptococci (27.1%), Staphylococcus aureus (22.0%), Citrobacter spp. (4.2%) and Neisseria meningitidis (0.9%). Prevalence of antibiotic resistance of S. pneumoniae ranged from 5.6% (ceftriaxone) to 58.3% (cotrimoxazole), M. catarrhalis ranged from 2.1% (gentamicin) to 80.6% (ampicillin), and S. aureus ranged from 7.7% (cefoxitin) to 100% (penicillin). The prevalence of multiple drug resistance was 16.7% for S. pneumoniae, 57.4% for M. catarrhalis and 84.6% for S. aureus. HIV infected children in the study area commonly carry multi-drug resistant isolates of several pathogenic bacteria such as S. aureus and S. pneumoniae. Infections arising in these patients that are caused by S. aureus and S. pneumoniae could be treated with ceftriaxone and cefoxitin respectively.</div></front></TEI><affiliations><list><country><li>Ghana</li></country><region><li>Région du Grand Accra</li></region><settlement><li>Accra</li></settlement><orgName><li>Université du Ghana</li></orgName></list><tree><country name="Ghana"><region name="Région du Grand Accra"><name sortKey="Sampane Donkor, Eric" sort="Sampane Donkor, Eric" uniqKey="Sampane Donkor E" first="Eric" last="Sampane-Donkor">Eric Sampane-Donkor</name></region><name sortKey="Annan, Jennifer Adoley" sort="Annan, Jennifer Adoley" uniqKey="Annan J" first="Jennifer Adoley" last="Annan">Jennifer Adoley Annan</name><name sortKey="Badoe, Ebenezer Vincent" sort="Badoe, Ebenezer Vincent" uniqKey="Badoe E" first="Ebenezer Vincent" last="Badoe">Ebenezer Vincent Badoe</name><name sortKey="Nii Trebi, Nicholas" sort="Nii Trebi, Nicholas" uniqKey="Nii Trebi N" first="Nicholas" last="Nii-Trebi">Nicholas Nii-Trebi</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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